منابع مشابه
Synaptic plasticity of kainate receptors.
Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA (N-methyl-D-aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors. The third subtype of ionotropic glutamate receptor, kainate receptors, has not been ...
متن کاملKainate receptors and synaptic transmission.
Excitatory glutamatergic transmission involves a variety of different receptor types, each with distinct properties and functions. Physiological studies have identified both post- and presynaptic roles for kainate receptors, which are a subtype of the ionotropic glutamate receptors. Kainate receptors contribute to excitatory postsynaptic currents in many regions of the central nervous system in...
متن کاملKainate receptors: knocking out plasticity.
There is increasing evidence that kainate receptors contribute to both postsynaptic and presynaptic signaling. Studies of knockout mice have played a pivotal role in defining the functions of kainate receptors, including a recent study that implicates kainate receptors in frequency-dependent facilitation and long-term potentiation of hippocampal mossy fiber synapses.
متن کاملSynaptic Targeting of Kainate Receptors.
When native and recombinant kainate receptors (KARs) are compared, there is a mismatch in several of their functional properties. While both generate currents, synaptic responses mediated by KARs have rarely observed in cultured hippocampal neurons. The recent discovery of auxiliary proteins for KARs, such as Netos, offers an explanation for these discrepancies. We found that the GluK5 KAR subu...
متن کاملKainate receptors: multiple roles in neuronal plasticity.
Ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have been extensively invoked in plasticity. Until relatively recently, however, kainate-type receptors (KARs) had been the most elusive to study because of the lack of appropriate pharmacological tools to specifically address their roles. With the development of selecti...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2021
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2021.108540